Faecal elastase 1 levels in premature and full term infants. Issue 2 (1st March 2003)

• Record Type: Journal Article
• Authors: Kori, M; Maayan-Metzger, A; Shamir, R; Sirota, L; Dinari, G
• Is Part Of: Archives of disease in childhood. Volume 88:Issue 2(2003)
• Page Start: F106
• Page End: F108
• Publication Date: 2003-03-01
• Subjects: premature -- faecal elastase 1 -- elastase 1 -- pancreas -- ontogenesis; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.88.2.F106
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : Background: Determination of faecal elastase 1 (FE1) is a simple, relatively inexpensive, non-invasive, highly specific and sensitive test for determining pancreatic function. Secretion of pancreatic enzymes varies during infancy, but there are almost no specific data on the ontogeny of elastase 1 in human babies. Aim: To study FE1 levels in preterm and term babies, and to determine the possible effect of gestational and postconceptual age on these levels. Methods: Serial stool samples were collected and tested for FE1 level from 77 premature and full term infants. FE1 levels were determined by a commercially available enzyme linked immunosorbent assay (ELISA) kit. Results: A total of 232 stool samples were collected from 77 neonates. The FE1 level measured in the first stool sample (meconium) was below normal (200 μg/g stool) in all samples regardless of gestational age. Sixty three neonates had at least two samples tested for FE1 level. The mean (SD) level of FE1 in sample 1 was 45.9 (51.1) μg/g stool and was significantly (p < 0.001) lower than in sample 2 (243.0 (164.9) μg/g stool). The lower the gestational age of the newborn, the more time it took for FE1 to reach normal levels. Conclusions: FE1 levels in meconium are low, and studies in meconium should be avoided if pancreatic sufficiency is to be determined. FE1 reaches normal levels by day 3 in term newborns and by 2 weeks in infants born before 28 weeks gestation. Normal levels are reached sooner in infants of more advanced gestational age who start enteral feeding earlier.