REPEAT ANTIBIOTIC DOSING IN PROLONGED PAEDIATRIC SURGERY—DO WE? SHOULD WE?. Issue 8 (11th July 2014)

• Record Type: Journal Article
• Authors: Aston, J; Terry, D; Lambert, B; Patel, P
• Is Part Of: Archives of disease in childhood. Volume 99:Issue 8(2014)
• Page Start: e3
• Page End: e3
• Publication Date: 2014-07-11
• Subjects: Neonatology -- Pharmacology; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2014-306798.10
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Aim: To evaluate the current practice of intra-operative repeat dosing of antibiotics during prolonged paediatric surgery. Method: The proportion of procedures that lasted longer than four hours were identified from anaesthetic records over a 12 week period. The medical notes, anaesthetic record and medication charts were retrospectively reviewed for a convenience sample of 50 patients. Data were collected on: speciality, the procedure undertaken, antibiotic(s) prescribed, timing of administration in relation to surgery and the timing of additional doses. The data were recorded using Excel and analysed by descriptive statistics. Results: A total of 3202 procedures were undertaken over 12 weeks with 163 (5.1%) lasting longer than 4 hours. The most common specialities were cardiac surgery (71/163, 43.6%), neurosurgery (23/163, 14.1%), hepatic and craniofacial surgery (13/163, 8.0% each). In the detailed analysis of 50 patients, the pre-operative dose was administered within 60 minutes prior to incision in 45/50 (90%) cases. A repeat intra-operative dose was administered in 3 (6%) procedures. These were cardiac, neurosurgical and orthopaedic procedures. All repeat doses were administered approximately 4 hours after the initial pre-operative dose. Conclusion: The practice of administering an intra-operative repeat dose of prophylactic antibiotics during prolonged surgery was not established practice. National guidance recommends a repeat intra-operative dose in surgery lasting longer than 4 hours or where the duration of surgery exceeds the half-life of the antibiotic administered.1 2 The evidence base for surgical prophylaxis in paediatric patients is limited, however, a repeat intra-operative dose should be considered in prolonged surgery.3 Current practice in paediatric surgery should be reviewed in order to consider the routine use of intra-operative doses of antibiotic prophylaxis.