Reduced plasma high-density lipoprotein and increased platelet activity in arterial versus venous blood. Issue 736 (February 1987)

• Record Type: Journal Article
• Authors: Aviram, M.; Viener, A.; Brook, J. G.
• Is Part Of: Postgraduate medical journal. Volume 63:Issue 736(1987)
• Page Start: 91
• Page End: 94
• Publication Date: 1987-02
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.63.736.91
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Plasma lipid and lipoprotein pattern and platelet activity were studied in blood samples derived from veins and arteries of 10 healthy male subjects. A significant reduction in plasma high-density lipoprotein (HDL) cholesterol, triglyceride and protein levels, as well as in plasma apolipoprotein A-I, was found when lipoproteins were derived from arterial blood in comparison to venous blood. All other lipoproteins were not significantly changed. Platelet activity measured as plasma beta-thromboglobulin levels and as collagen-induced platelet aggregation and 14C-serotonin release in platelet-rich plasma was markedly elevated when platelets were derived from arterial blood. Since reduced plasma HDL concentration and platelet activation are known risk factors for atherosclerosis, our study may suggest a further explanation for the presence of atherosclerotic lesions in arteries but not in veins.