Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?. Issue 12 (16th November 2006)

• Record Type: Journal Article
• Authors: Ulla, M; Thobois, S; Lemaire, J-J; Schmitt, A; Derost, P; Broussolle, E; Llorca, P-M; Durif, F
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 77:Issue 12(2006)
• Page Start: 1363
• Page End: 1366
• Publication Date: 2006-11-16
• Subjects: DBS, deep-brain stimulation -- DSM IV, Diagnostic and statistical manual—4th edn -- HFS, high-frequency stimulation -- MRI, magnetic resonance imaging -- PET, positron emission tomography -- rCBF, regional cerebral blood flow -- STN, subthalamic nucleus; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.2006.096628
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.