Bone disease after jejuno-ileal bypass for morbid obesity. Issue 691 (May 1983)

• Record Type: Journal Article
• Authors: Gilmore, I. T.; Eastwood, J. B.; Ellis, W. R.; Luck, V. A.; Fenton, S.; O'Grady, A. J.; Harris, E.; Murray-Lyon, I. M.
• Is Part Of: Postgraduate medical journal. Volume 59:Issue 691(1983)
• Page Start: 299
• Page End: 303
• Publication Date: 1983-05
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.59.691.299
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Fifteen patients who had undergone a 14 inches X 4 inches jejuno-ileal bypass operation for obesity, 3 to 4 years earlier, were investigated by iliac bone biopsy, radiology and routine biochemistry, including 25-hydroxy-vitamin D and parathyroid hormone estimations. Two patients had histological osteomalacia which was mild in one. A further 9 patients had abnormal bone biopsies, there being an excess of trabecular bone surface covered by osteoid with a normal or reduced amount of calcification front. Six of these 9 showed an increase in trabecular resorption, although in none were there excessive numbers of osteoclasts. The likely explanation for these findings is that these 9 patients had early osteomalacia with mild hyperparathyroidism, making a total of 11 patients out of 15 with osteomalacia. Radiology and blood chemistry were poor predictors of histological bone disease.