Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand. Issue 9 (29th April 2018)

• Record Type: Journal Article
• Authors: Jongkhajornpong, Passara; Lekhanont, Kaevalin; Pisuchpen, Phattrawan; Chantaren, Patchima; Puangsricharern, Vilavun; Prabhasawat, Pinnita; Suphapeetiporn, Kanya; Kinoshita, Shigeru; Ueta, Mayumi
• Is Part Of: British journal of ophthalmology. Volume 102:Issue 9(2018)
• Page Start: 1303
• Page End: 1307
• Publication Date: 2018-04-29
• Subjects: Stevens-Johnson syndrome -- cold medicine -- severe ocular complications -- human leucocyte antigen; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2017-311823
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Background: Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOC). Because ethnic differences in genetic predisposition to SJS/TEN among different populations have been proposed, we focused on Thai patients and investigated the association between HLA class I genotypes and CM-SJS/TEN with SOC. Methods: This multicentre case–control study was conducted between September 2014 and August 2017. Seventy-one Thai patients with SJS/TEN with SOC and 159 healthy Thai controls were enrolled. HLA typing was performed. Genetic relationships were analysed using Fisher's exact test. Results: Of 71 patients with SJS/TEN with SOC (28 male, 43 female), 49 (69%) had a history of taking cold medications prior to SJS/TEN onset. The mean age of onset was 26.7±17.1 years (range, 2–77 years). HLA-B*44:03 (OR, 7.2, p=5.5×10 -6, pc=1.1×10 -4 ) and HLA-C*07:01 (OR, 6.1, p=7.1×10 -6, pc=1.1×10 -4 ) showed significant positive associations with Thai patients with CM-SJS/TEN with SOC. Additionally, 17 of 49 patients with CM-SJS/TEN with SOC (34.7%) significantly harboured the HLA-B*44:03 and HLA-C*07:01 haplotype compared with only 11 of 159 healthy controls (6.9%) (OR=7.1, p=5.5×10 -6 ). Conclusions: HLA-B*44:03-HLA-C*07:01 haplotype is a potential risk factor for CM-SJS/TEN with SOC in the Thai population. This study supports that HLA-B*44:03 might be a common marker for CM-SJS/TEN with SOC in Eurasia populations, including European, Indian, Japanese and Thai.