Zinc acetate as a precipitant of unstable haemoglobins. Issue 7 (July 1981)

• Record Type: Journal Article
• Authors: Carrell, R W; Lehmann, H
• Is Part Of: Journal of clinical pathology. Volume 34:Issue 7(1981)
• Page Start: 796
• Page End: 799
• Publication Date: 1981-07
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.34.7.796
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Whereas the addition of four moles of zinc acetate to one of normal human haemoglobin at pH 7.4 results in a clear solution, addition to unstable haemoglobin results in precipitate formation. Within certain limits no false-positive results are obtained with methaemoglobin, and with fetal haemoglobin. With excess zinc, normal haemoglobin also precipitates, but this process is reversible and can be used for a rapid concentration of dilute solutions of normal haemoglobin.