Rifampicin-induced upper gastrointestinal bleeding. Issue 774 (April 1990)

• Record Type: Journal Article
• Authors: Zargar, S. A.; Thapa, B. R.; Sahni, A.; Mehta, S.
• Is Part Of: Postgraduate medical journal. Volume 66:Issue 774(1990)
• Page Start: 310
• Page End: 311
• Publication Date: 1990-04
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.66.774.310
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Gastrointestinal disturbances like anorexia, nausea, vomiting, abdominal discomfort and diarrhoea are known adverse effects of rifampicin. We report an upper gastrointestinal bleeding due to haemorrhagic gastric erosions after ingestion of rifampicin for pulmonary tuberculosis. The cause and effect relationship between development of haemorrhagic gastric erosions and rifampicin administration was confirmed by rechallenge with rifampicin. To our knowledge no such adverse effect of rifampicin has been reported previously.