Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis. Issue 11 (November 1986)

• Record Type: Journal Article
• Authors: Brett, M M; Ghoneim, A T; Littlewood, J M
• Is Part Of: Archives of disease in childhood. Volume 61:Issue 11(1986)
• Page Start: 1114
• Page End: 1120
• Publication Date: 1986-11
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.61.11.1114
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20, 500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis.