Brugada syndrome associated with an autonomic disorder. (1st August 1998)

• Record Type: Journal Article
• Authors: Nomura, M; Nada, T; Endo, J; Kondo, Y; Yukinaka, M; Saito, K; Ito, S; Mori, H; Nakaya, Y; Shinomiya, H
• Is Part Of: Heart. Volume 80(1998)Supplement 2
• Page Start: 194
• Page End: 196
• Publication Date: 1998-08-01
• Subjects: Brugada syndrome -- autonomic disorder -- 123I-MIBG myocardial scintigraphy; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.80.2.194
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123 I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15–0.40 Hz), an index of parasympathetic nerve activity, was observed just before ST segment elevation. In addition, local dysfunction of sympathetic nerves in the left ventricle was detected by 123 I-MIBG myocardial scintigraphy. Unbalanced autonomic nerve function plays an important role in inducing Brugada-type ECG signs.