Angiofollicular and plasmacytic polyadenopathy: a pseudotumourous syndrome with dysimmunity. Issue 11 (November 1980)

• Record Type: Journal Article
• Authors: Diebold, J; Tulliez, M; Bernadou, A; Audouin, J; Tricot, G; Reynes, M; Bilski-Pasquier, G
• Is Part Of: Journal of clinical pathology. Volume 33:Issue 11(1980)
• Page Start: 1068
• Page End: 1076
• Publication Date: 1980-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.33.11.1068
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Two cases are reported of an apparently distinct type of immune disorder. Beginning with mild anaemia and widespread massive lymphadenopathy, the disease progressed to a fatal autoimmune type haemolytic anaemia. Serum investigation showed polyclonal hypergamma-globulinaemia and some autoantibodies. Repeat lymph node biopsies in each case showed hyperplasia within B lymphocyte territory (follicular hyperplasia and polyclonal plasmacytosis with IgG predominance) and atrophy of T dependent areas. Dilatation of lymph sinuses, vascular proliferation, and sclerosis were striking features. This appears to be a new entity, and reasons are given for separating this disease from other pseudotumourous lymph node disorders associated with dysimmunity.