Neonatal hypocalcaemia associated with maternal hyperparathyroidism. New pathogenetic observations. Issue 4 (April 1978)

• Record Type: Journal Article
• Authors: Jacobsen, B B; Terslev, E; Lund, B; Sørensen, O H
• Is Part Of: Archives of disease in childhood. Volume 53:Issue 4(1978)
• Page Start: 308
• Page End: 311
• Publication Date: 1978-04
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.53.4.308
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatment with calcium and vitamin D, serum PTH and 25-OHD3 concentrations increased markedly before serum calcium levels returned to normal perhaps indicating an inability to convert 25-OHD3 to the metabolically active 1, 25-dihyroxyvitamin D3 during the hyperphosphataemic state. Treatment with 1, 25-dihdroxyvitamin D3 or its analogues is recommended.