Histochemical investigation into the molecular mechanisms of malignant transformation in a benign glomus tumour. Issue 11 (November 1998)

• Record Type: Journal Article
• Authors: Hegyi, L; Cormack, G C; Grant, J W
• Is Part Of: Journal of clinical pathology. Volume 51:Issue 11(1998)
• Page Start: 872
• Page End: 874
• Publication Date: 1998-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.51.11.872
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A glomangiosarcoma arose in a benign glomus tumour. The histological and immunohistochemical characteristics of the tumour were investigated. Apoptotic cells were identified by terminal deoxynucleotidyl transferase (TdT) mediated dUTP-biotin nick end labelling (TUNEL). The proportion of apoptotic cells was found to be low and TUNEL positive nuclei were present in the benign part of the tumour. Bcl-2 protein, an inhibitor of apoptosis, was strongly expressed in the glomangiosarcoma with only weak staining in the benign area. The proliferation index of the glomangiosarcoma was almost 10-fold higher than that of the benign glomus tumour. Numerous nuclei in the glomangiosarcoma were intensely stained for the tumour suppressor protein p53. The results of the this study may contribute to an understanding of the molecular basis of malignant transformation in benign glomus tumours.