No evidence of HTLV-I infection in French patients with multiple sclerosis using the polymerase chain reaction. Issue 10 (October 1991)

• Record Type: Journal Article
• Authors: Wattel, E; Mariotti, M; Bignon, J D; Agis, F; Gordien, E; Muller, J Y; Hors, J; Lefrère, J J
• Is Part Of: Journal of clinical pathology. Volume 44:Issue 10(1991)
• Page Start: 871
• Page End: 872
• Publication Date: 1991-10
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.44.10.871
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The polymerase chain reaction (PCR), using three primer pairs in the pol, tax, and env regions of the HTLV-I genome, was unable to detect HTLV-I in the blood samples of 54 caucasian subjects with multiple sclerosis who were seronegative for HTLV-I/II. Seventeen HTLV-I/II seropositive (by ELISA and Western blot) subjects used as positive controls were positive with the three primer pairs. The PCR was negative in 47 healthy HTLV-I/II seronegative (by ELISA) subjects at low risk of HTLV-I infection used as negative controls. These results suggest that there is no association between the occurrence of HTLV-I sequences and the development of multiple sclerosis.