The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes. Issue 6 (25th February 2016)

• Record Type: Journal Article
• Authors: Kalimuthu, Sangeetha N; Serra, Stefano; Dhani, Neesha; Chetty, Runjan
• Is Part Of: Journal of clinical pathology. Volume 69:Issue 6(2016)
• Page Start: 463
• Page End: 471
• Publication Date: 2016-02-25
• Subjects: CARCINOMA -- PANCREAS -- CHEMOTHERAPY; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2016-203604
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.