A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. (1st October 2001)

• Record Type: Journal Article
• Authors: Kelly, S; Harris, K M; Berry, E; Hutton, J; Roderick, P; Cullingworth, J; Gathercole, L; Smith, M A
• Is Part Of: Gut. Volume 49(2001)Supplement 4
• Page Start: 534
• Page End: 539
• Publication Date: 2001-10-01
• Subjects: endoscopic ultrasound -- gastro-oesophageal cancer -- TNM staging -- systematic literature review -- meta-analysis; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.49.4.534
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : BACKGROUND: Endoscopic ultrasound (EUS) may be used for preoperative staging of gastro-oesophageal carcinoma but performance values given in the literature differ. AIMS: To identify and synthesise findings from all articles on the performance of EUS in tumour, node, metastasis (TNM) staging of gastro-oesophageal carcinoma. SOURCE: Published and unpublished English language literature, 1981–1996. METHODS: Data on the staging performance of EUS were retrieved and evaluated. Summary receiver operator characteristic methodology was used for synthesis, and a summary estimate of performance, Q*, obtained. Multiple regression analysis was used to assess study validity and investigate reasons for differences in performance. RESULTS: Twenty seven primary articles were assessed in detail. Thirteen supplied results for staging oesophageal cancer, 13 for gastric cancer, and four for cancers at the gastro-oesophageal junction. For gastric T staging, Q*=0.93 (95% confidence interval (CI) 0.91–0.95) and for oesophageal T staging, Q*=0.89 (95% CI 0.88–0.92). For gastro-oesophageal T staging, including cancers at the gastro-oesophageal junction, Q*=0.91 (95% CI 0.89–0.93). Inclusion of cases with non-traversable stenosis was found to slightly reduce staging performance. For N staging, Q*=0.79 (95% CI 0.75–0.83). In articles that compared EUS directly with incremental computed tomography, EUS performed better. None of the variables assessed in the regression analysis was significant using a Bonferroni correction. Three variables (anatomical location, traversability, and blinding) showed strong relationships for future research and validation. CONCLUSIONS: EUS is highly effective for discrimination of stages T1 and T2 from stages T3 and T4 for primary gastro-oesophageal carcinomas. The failure rate of EUS from non-traversability of a stenotic cancer may be a limitation in some patient groups.