Inheritance and influence of histocompatibility (HL-A) antigens in adult coeliac disease. Issue 8 (August 1973)

• Record Type: Journal Article
• Authors: Stokes, P. L.; Asquith, P.; Holmes, G. K. T.; Mackintosh, Pauline; Cooke, W. T.
• Is Part Of: Gut. Volume 14:Issue 8(1973)
• Page Start: 627
• Page End: 630
• Publication Date: 1973-08
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.14.8.627
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : In a study of histocompatibility antigens in adult coeliac disease the HL-A phenotypes have been determined in 117 patients and 149 of their first-degree relatives, of whom 94 had had a jejunal biopsy performed. There was an increased frequency of the HL-A 8 antigen in the patients and their relatives. Family studies showed no irregularity in the inheritance of both this antigen and the HL-A 1 and 8 haplotype.