Age-related response to 1000 CCA unit zonally purified, inactivated influenza vaccines in volunteers in the U.S.A. Issue 569 (March 1973)

• Record Type: Journal Article
• Authors: Marine, William M.; Thomas, James E.
• Is Part Of: Postgraduate medical journal. Volume 49:Issue 569(1973)
• Page Start: 164
• Page End: 168
• Publication Date: 1973-03
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.49.569.164
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Response to 1000 CCA unit Aichi/68 and Japan/57 influenza vaccines was studied in 687 volunteers from ages 6-101 in the summer of 1971. The vaccines, prepared by zonal ultracentrifugation, were well tolerated in all age-groups. Antibody responses were comparable with each vaccine and were strongly influenced by age of the volunteer. Persons born since 1940 (age 31 and under) had a much more impressive response as determined by both overall geometric mean titre rise and% with ≥ four-fold increase in titre than persons born before 1940. The most reasonable explanation for this phenomenon seems to be the greater prior exposure of the younger age-groups to the strains in the vaccines. It is concluded that more attention needs to be given in the future to assessing vaccine potency in the age-groups for which the maximum protection is desired, namely, the elderly.