Biomaterials for Personalized Cell Therapy. Issue 13 (9th September 2019)

• Record Type: Journal Article
• Authors: Facklam, Amanda L.; Volpatti, Lisa R.; Anderson, Daniel G.
• Is Part Of: Advanced materials. Volume 32:Issue 13(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-09
• Subjects: biomaterials -- cell therapy -- drug delivery -- immunotherapy -- personalized medicine -- regenerative medicine; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201902005
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include mesenchymal stem cells for tissue regeneration, islet transplantation for diabetes treatment, and T cell delivery for cancer immunotherapy. Biomaterials have the potential to extend the therapeutic impact of cell therapies by serving as carriers that provide 3D organization and support cell viability and function. With the growing emphasis on personalized medicine, cell therapies hold great potential for their ability to sense and respond to the biology of an individual patient. These therapies can be further personalized through the use of patient‐specific cells or with precision biomaterials to guide cellular activity in response to the needs of each patient. Here, the role of biomaterials for applications in tissue regeneration, therapeutic protein delivery, and cancer immunotherapy is reviewed, with a focus on progress in engineering material properties and functionalities for personalized cell therapies. Abstract : Biomaterials enable personalized cell therapies with applications in tissue regeneration, therapeutic protein delivery, and immunotherapy. Personalized cell therapies provide localized, dynamic treatment through their innate ability to sense and respond to their microenvironment and orchestrate complex biological processes. Biomaterials to support cell viability and functionality and to instruct cell behavior including differentiation from induced pluripotent stem cells are under development.