European Ultrahigh‐Field Imaging Network for Neurodegenerative Diseases (EUFIND). Issue 1 (31st July 2019)

• Record Type: Journal Article
• Authors: Düzel, Emrah; Acosta‐Cabronero, Julio; Berron, David; Biessels, Geert Jan; Björkman‐Burtscher, Isabella; Bottlaender, Michel; Bowtell, Richard; Buchem, Mark v; Cardenas‐Blanco, Arturo; Boumezbeur, Fawzi; Chan, Dennis; Clare, Stuart; Costagli, Mauro; de Rochefort, Ludovic; Fillmer, Ariane; Gowland, Penny; Hansson, Oskar; Hendrikse, Jeroen; Kraff, Oliver; Ladd, Mark E.; Ronen, Itamar; Petersen, Esben; Rowe, James B.; Siebner, Hartwig; Stoecker, Tony; Straub, Sina; Tosetti, Michela; Uludag, Kamil; Vignaud, Alexandre; Zwanenburg, Jaco; Speck, Oliver;
• Other Names: Jovicich Jorge guestEditor.; Frisoni Giovanni B. guestEditor.
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 1(2019)
• Page Start: 538
• Page End: 549
• Publication Date: 2019-07-31
• Subjects: Magnetic resonance imaging (MRI) -- Ultrahigh‐field MRI -- Alzheimer's disease (AD) -- Subjective cognitive decline (SCD) -- Mild cognitive impairment (MCI) -- Parkinson's disease (PD) -- Vascular dementia; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2019.04.010
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: The goal of European Ultrahigh‐Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh‐field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use‐cases for clinical applications in neurodegeneration.