Neutrophil: Lymphocyte ratio as a method of predicting complications following hepatic resection for colorectal liver metastasis. Issue 5 (15th February 2018)

• Record Type: Journal Article
• Authors: McCluney, Simon J.; Giakoustidis, Alexandros; Segler, Angela; Bissel, Juliane; Valente, Roberto; Hutchins, Robert R.; Abraham, Ajit T.; Bhattacharya, Satyajit; Kocher, Hemant M.
• Other Names: Rocha Flavio guestEditor.; Coimbra Felipe guestEditor.; de Castro Ribeiro Héber Salvador guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 117:Issue 5(2018)
• Page Start: 1058
• Page End: 1065
• Publication Date: 2018-02-15
• Subjects: colorectal cancer -- hepatectomy -- liver resection -- outcome; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.24996
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Background and Objectives: Approximately 30‐50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). Methods: We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016. Baseline demographics and complications within 30 days following surgery were recorded, with blood tests measured until day 7. Statistical analysis was performed using Mann Whitney and ROC analysis. Results: One hundred eighty‐eight operations were included. 47.3% had an associated complication, of which 31.46% were major. The median NLR was 6.31 across the cohort, 5.44 for uncomplicated procedures, 7.0 for complications and 10.65 in major complications. Median NLR was the best parameter for detecting major complications versus minor complications (AUC 0.74) as opposed to lymphocytes (AUC 0.65), neutrophils (AUC 0.60), and CRP (AUC 0.60). The diagnostic ability of NLR increased further when predicting major complications versus an uncomplicated recovery (AUC 0.78), and it was the only significant parameter in the early post‐operative period on days 2, 3, and 4 (AUC 0.70, 0.72, and 0.75). Conclusions: The NLR may have a role in predicting complications following hepatic resection for CLM, and with earlier detection, potentially improving outcomes.