Inside Cover: Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye‐Labeled Cargo (Angew. Chem. Int. Ed. 12/2020). Issue 12 (27th January 2020)

• Record Type: Journal Article
• Authors: Jeevarathinam, Ananthakrishnan Soundaram; Lemaster, Jeanne E.; Chen, Fang; Zhao, Eric; Jokerst, Jesse V.
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 12(2020)
• Page Start: 4594
• Page End: 4594
• Publication Date: 2020-01-27
• Subjects: antitumor agents -- cancer therapy -- drug delivery -- paclitaxel -- photoacoustic imaging; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202000870
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Photoacoustic imaging enables a new strategy to monitor drug delivery, as reported by J. V. Jokerst and co‐workers in their Communication on page 4678 . Here, the paclitaxel drug is tagged with redox‐active methylene blue. This drug–dye conjugate was sealed inside a poly(lactic‐ co ‐glycolic acid) nanocarrier in the reduced state where it does not absorb light. When the drug–dye conjugate is released, the dye is oxidized to report the location and quantity of the cargo.