GP275 Pediatric spray-sol: a new nebulization device specific for upper respiratory tract infections. (June 2019)

• Record Type: Journal Article
• Authors: Moffa, Antonio; Grimaldi, Valentina; Rinaldi, Vittorio; Lopez, Michele Antonio; Sabatino, Lorenzo; Costantino, Andrea; Cassano, Michele; Casale, Manuele
• Is Part Of: Archives of disease in childhood. Volume 104:(2019)Supplement 3
• Page Start: A145
• Page End: A145
• Publication Date: 2019-06
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2019-epa.334
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background: Upper respiratory tract infections (URTI) are very common in the pediatric population due to their 'physiologically' immature immune system; yet, around 90% are viral – only 10% of URTI are bacterial. Therefore, treatment should essentially be symptomatic to relieve the child's discomfort and symptoms. Topical, rather than system, treatment is preferable reducing systemic effects and increasing the topical efficacy. There are many different nasal devices used to treat URTI, but often they are not specifically targeted for this purpose. Objective: Our group developed a new nebulization device, called 'Pediatric spray-sol', target specificity, very speed, pocked-size and portable, mono-patient without sterilization problems with the ability to vary concentration and quantity of medication in delivery, to combine substances in a single treatment. Materials and Methods: The device can be used in combination with a common syringe (without needle), without need for electricity. The user operates the plunger of the syringe to push the liquid drug into the delivery device. Once inside, the substance is nebulized and, from there, delivered into the nose in aerosol form. The device includes a fluidodynamic path with an expansion chamber and an acceleration chamber arranged in sequence, which allows for the optimum delivery of fluid. Results: The features of Spray- Sol include: the ability to nebulize high viscosity substances similarly an aerosol, nebulize particles of average diameter between 10 and 20 microns, the very low administration times (10 seconds to 5 cc of substance), the cost and the possibility of use for all the duration of the treatment, it is portable and doesn't need electricity.This nasal nebulizer provides a more extensive and intensive delivery of solution in the nasal cavities, especially the deeper and higher portions of nasal cavity. In particular, pediatric Spray-sol, seem to guarantee a homogeneous distribution of drug at the middle turbinate and ostiomeatal complex crucial region for the drainage and ventilation of the paranasal sinuses. Spray-Sol reaches more easily the nasopharynx subsite and it could be considered a useful device for adenoiditis and Eustachian tube dysfunction. Moreover, it can quickly and efficiently nebulize not only salin solutions but others substances like hyaluronic acid, ectoine and corticosteroids. Conclusions: Pediatric Spray-sol is a new nebulization device for URTI treatment: combining the comfort of a spray with the efficacy of an aerosol. Pediatric Spray-sol can be used to deliver any type of solution in the nose such as saline solutions, hyaluronic acid, ectoine and corticosteroids.