P603 Uropathogen profile in the paediatric population – a comparative study between two geographically distinct regions in Ireland. (June 2019)

• Record Type: Journal Article
• Authors: Allawendy, Samy AA; Farhan, Mahmoud; Biagini, Alessandra; Riaz, Abdullah; Rueda-Benito, Ana Isabel; Collins, Cathal; Logan, Karen; McDonald, Briain; Greaney, Hilary; Harrison, Ghia; Finan, Alan
• Is Part Of: Archives of disease in childhood. Volume 104:(2019)Supplement 3
• Page Start: A393
• Page End: A393
• Publication Date: 2019-06
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2019-epa.935
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background: Urinary tract infection (UTI) is one of the most common bacterial infections among children. The high level of antimicrobial resistance in uropathogens worldwide is a cause for real concern. Currently empirical first line antibiotics used for UTI in children are similar in most hospitals. There is limited data in relation to geographical variation in uropathogen prevalence and their antimicrobial sensitivity. This study aims to evaluate and compare the prevalence and resistance pattern of UTI pathogens in two geographically distinct areas in Ireland. Methods: Paediatric patients admitted with an uncomplicated laboratory confirmed UTI at Sligo University Hospital and Cavan General Hospital between January 2017 and December 2018 were reviewed; Patients with structurally or neurologically complicated urinary tracts were excluded from this study. Antimicrobial susceptibility to Amox-clavulanate, Amoxycillin, Ceftazidime Fosfomycin, Gentamicin, Nitrofurantoin, and Trimethoprim was determined for urinary isolates. Results: Profiles of organisms and antimicrobial sensitivities in Sligo and Cavan patients were broadly similar but with some differences., Escherichia coli was the most prevalent pathogen contributing to UTIs representing 80.22% and 87.34% of isolates in Sligo and Cavan respectively. Highest rates of resistance were noted to Amoxycillin (49.45% and 62.03% respectively) and co-Amox-clavulanate (42.86% and 41.77%). Highest rates of antimicrobial sensitivity for isolates from Sligo were for Nitrofurantoin (91.2%), followed by Fosfomycin (90.11%) while in Cavan, they were for Gentamicin (96.2%) followed by Nitrofurantoin and Ceftazidime (92.4% both). Conclusions: High resistance was observed to Amoxycillin and co- Amox-clavulanate which are commonly used as empirical treatments for UTIs. It may be timely to review our local empirical antibiotic choices. The results of this small study in two local acute paediatrics services would indicate it may be useful to conduct a wider national review of uropathogen patterns and sensitivities in the paediatric population.