SAT0287 Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren: Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project). (15th July 2016)

• Record Type: Journal Article
• Authors: Brito-Zerόn, P.; Acar-Denizli, N.; Zeher, M.; Rasmussen, A.; Seror, R.; Mandl, T.; Li, X.; Baldini, C.; Gottenberg, J.-E.; Danda, D.; Quartuccio, L.; Priori, R.; Hernández-Molina, G.; Kruize, A.; Valim, V.; Kvarnstrom, M.; Sene, D.; Gerli, R.; Praprotnik, S.; Isenberg, D.; Solans, R.; Rischmueller, M.; Park, S.-H.; Nordmark, G.; Suzuki, Y.; Giacomelli, R.; Saraux, A.; Bombardieri, M.; Hofauer, B.; Bootsma, H.; Hammenfors, D.; Fraile, G.; Carsons, S.; Gheita, T.; Morel, J.; Vollenveider, C.; Atzeni, F.; Retamozo, S.; Horvath, I.-F.; Sivils, K.; Theander, E.; Sandhya, P.; De Vita, S.; Sanchez-Guerrero, J.; van der Heijden, E.; Moça-Trevisano, V.; Wahren-Herlenius, M.; Mariette, X.; Ramos-Casals, M.;
• Is Part Of: Annals of the rheumatic diseases. Volume 75(2016)Supplement 2
• Page Start: 772
• Page End: 772
• Publication Date: 2016-07-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2016-eular.2884
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To analyse the influence of ethnicity on the clinical presentation at diagnosis in an international cohort of patients with primary Sjögren syndrome (pSS). Methods: The Big Data Sjögren Project is a multicentre registry formed by international experts from the EULAR-SS Task Force. By January 2016, the database included 8315 consecutive patients fulfilling the 2002 AE criteria (20 countries, 5 continents). Ethnicity was classified according to FDA (White=W, Black/African American=B, Asian=A, Hispanic=H, Others=O). Results: Ethnicity data was available in 7887 (95%) patients: 6177 W (78%), 1066 A (13%), 393 H (5%), 104 B (1%) and 147 O (2%). European patients were overwhelmingly white compared with Americans (96% vs 52%, p<0.001). The greatest differences between ethnicities (p<0.001) were observed for mean age at diagnosis (47yrs in B vs 54yrs in W), and the frequency of males (12% in B vs 4% in A), dry eyes (76% in A vs 98% in O), dry mouth (83% in A vs 99% in O), abnormal ocular tests (79% in O vs 90% in H), abnormal oral tests (65% in O vs 91% in H), positive minor salivary biopsy (75% in O vs 95% in H), positive anti-Ro (54% in O vs 84% in A) and positive anti-La (28% in O vs 50% in A). Conclusions: White patients had the oldest age at diagnosis, Black/African Americans the highest frequency of men and the lowest mean age, Asians the highest frequency of women, the lowest frequency of sicca symptoms and the highest frequency of Ro/La and Hispanics the highest frequency of abnormal diagnostic tests. Ethnicity plays a capital role in the phenotypic expression at diagnosis of primary SS. Disclosure of Interest: None declared