P344 Evaluation of vitamin d deficiency prevalance and efficiency of therapeutic intervention in cystic fibrosis paediatric patients. (6th June 2017)

• Record Type: Journal Article
• Authors: Ritivoiu, Mirela; Comanici, Daniela Valentina; Codreanu, Ioana Florentina; Vasile, Ana Maria; Delia, Corina; Craiu, Mihai; Stan, Iustina
• Is Part Of: Archives of disease in childhood. Volume 102(2017)Supplement 2
• Page Start: A166
• Page End: A166
• Publication Date: 2017-06-06
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2017-313273.432
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Background and aims: Current recommendation in managing CF patients regarding Vitamin D status ( 2005 European Consensus) are annually Vitamin D, Calcium and electrolytes identifications with prompt therapeutic intervention. Methods: 1 year retrospective Study with 68 children included (29 girls and 39 boys ) in which annual determination of Vitamin D was conducted. All children between 1 year and 18 years were included, with a medium age of 7.9 years. In patients with significant vitamin D deficiency identified treatment with high Vitamin D daily dose was established (btw. 2000-4000UI/d) and 6 Months close monitoring was conducted. results: In 15% severe Vitamin D deficiency was identified (<20 nmol/L), moderate vitamin D deficiency ( values btw. 20–75 nmol/L) was found in 47% and normal Vitamin D levels were determined in 38% of included children. Recommended treatment with 6 months monitoring highlighted that 35% of the Vitamin D deficiency group did not recover the normal levels of Vitamin D despite correct initiated treatment. Conclusions: Vitamin D deficiency is frequent among cystic fibrosis patients, 15% of them having severe deficiency. Recovering the deficit should include, besides Vitamin D supplementing, interventions on all the other factors involved in absorption of Vitamin D in cystic fibrosis children.