AB0769 Assessment of Sequels of poliomyelitis in Hips by 3D-DXA. (15th July 2016)

• Record Type: Journal Article
• Authors: Erra, A.; Grados, D.; Lopez-Vives, L.; Martelli, Y.; Humbert, L.; Pasarin, A.; Allue, N.; Di Gregorio, S.; del Rio, L.
• Is Part Of: Annals of the rheumatic diseases. Volume 75(2016)Supplement 2
• Page Start: 1167
• Page End: 1168
• Publication Date: 2016-07-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2016-eular.5914
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Polio is a devastating infectious disease that causes paralysis and severe muscular atrophy. When any of the legs is affected, a low aBMD at the corresponding hip is a common finding in DXA measurement. Objectives: to study the influence of polio consequences on volumetric bone density and cortical thickness using the 3D-DXA technology. Methods: 22 patients of both sexes suffering post-polio syndromes (mean age 57±uffering pos were scanned using a GE iDXA system and both proximal femurs were reconstructed using the 3D-DXA technology. 3D-DXA is based on the registration of a 3D statistical model of the femoral shape and density onto the 2D DXA image and provides measurements of volumetric BMD (vBMD) and BMCof the trabecular and cortical bone as well as a quantification of the cortical thickness. The measurements at the leg affected by polio were compared by t-test with those at the non-affected leg. Results: Trabecular BMC was 22% lower (-1.8 g, p<0.01) and cortical BMC 19% lower (-2.9 g, p<0.01) at the polio leg (total hip region). Similar findings were observed for the vBMD: 18% decrease (-0.020 g/cm 3, p<0.01) at the trabecular region and a 2.3% decrease for the cortical bone (-0.024 g/cm 3, p<0.01). The proximal femur volume was also inferior (-12%, -9 cm 3, p<0.01). The cortical thickness was thinner at the polio leg (-12%, -0.2 mm, p<0.01). Conclusions: A long period of decreased of mechanical charges, low muscle strength, postural imbalance has dramatic consequences on bone development. The analyses performed using the 3D-DXA technology indicates an overall impairment of cortical and trabecular BMD and a significant decrease of the cortical thickness. Disclosure of Interest: None declared