Tissue engineering for tendon repair. Issue 8 (24th October 2006)

• Record Type: Journal Article
• Authors: Bagnaninchi, Pierre-Olivier; Yang, Ying; El Haj, Alicia J; Maffulli, Nicola
• Is Part Of: British journal of sports medicine. Volume 41:Issue 8(2007)
• Page Start: e10
• Page End: e10
• Publication Date: 2006-10-24
• Subjects: bFGF, basic fibroblast growth factor -- BMP, bone morphogenetic protein -- ECM, extracellular matrix -- MMP, matrix metalloproteinase -- MSC, mesenchymal stem cell -- PDGF, platelet-derived growth factor; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2006.030643
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.