Composite self-expanding bioresorbable prototype stents with reinforced compression performance for congenital heart disease application: Computational and experimental investigation. (August 2018)

• Record Type: Journal Article
• Authors: Zhao, Fan; Xue, Wen; Wang, Fujun; Liu, Laijun; Shi, Haoqin; Wang, Lu
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 84(2018)
• Page Start: 126
• Page End: 134
• Publication Date: 2018-08
• Subjects: Composite bioresorbable stent -- Reinforced compression performance -- Congenital heart disease -- Computational simulation; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2018.05.009
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Stents are vital devices to treat vascular stenosis in pediatric patients with congenital heart disease. Bioresorbable stents (BRSs) have been applied to reduce challenging complications caused by permanent metal stents. However, it remains almost a total lack of BRSs with satisfactory compression performance specifically for children with congenital heart disease, leading to importantly suboptimal effects. In this work, composite bioresorbable prototype stents with superior compression resistance were designed by braiding and annealing technology, incorporating poly ( p- dioxanone) (PPDO) monofilaments and polycaprolactone (PCL) multifilament. Stent prototype compression properties were investigated. The results revealed that novel composite prototype stents showed superior compression force compared to the control ones, as well as recovery ability. Furthermore, deformation mechanisms were analyzed by computational simulation, which revealed bonded interlacing points among yarns play an important role. This research presents important clinical implications in bioresorbable stent manufacture and provides further study with an innovative stent design.