Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. Issue 15 (1st August 2015)

• Record Type: Journal Article
• Authors: Lee, Young Hun; Kim, Hyoung Ja; Yoo, Ho; Jung, Seo Yun; Kwon, Bong Jin; Kim, Nam-Jung; Jin, Changbae; Lee, Yong Sup
• Is Part Of: Bioorganic & medicinal chemistry. Volume 23:Issue 15(2015)
• Page Start: 4970
• Page End: 4979
• Publication Date: 2015-08-01
• Subjects: Quercetin 3-O-methyl ether -- Aminoethyl -- Antioxidant -- Neuroprotection -- MCAO model; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2015.05.023
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Reactive oxygen species have been implicated in several diseases, particularly in ischemia-reperfusion injury. Quercetin 3- O -methyl ether has been reported to show potent antioxidant and neuroprotective activity against neuronal damage induced by reactive oxygen species. Several aminoethyl-substituted derivatives of quercetin 3- O -methyl ether have been synthesized to increase water solubility while retaining antioxidant and neuroprotective activity. Among such derivatives, compound 3a shows potent and well-balanced antioxidant activity in three types of cell-free assay systems and has in vivo neuroprotective effects on transient focal ischemic injury induced by the occlusion of the middle cerebral artery in rats.