AISA can control the inflammatory facet of SASP. (March 2020)

• Record Type: Journal Article
• Authors: d'Alessio, Patrizia A.; Béné, Marie C.
• Is Part Of: Mechanisms of ageing and development. Volume 186(2020)
• Publication Date: 2020-03
• Subjects: Inflammatory markers -- Endothelial cells -- Senescence -- Adhesion molecules -- Cytoskeleton -- Pro-inflammatory cytokines -- Mood modulation -- Vagus tone; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2019.111206
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Chronic inflammation contributes to the instauration of aging-related diseases and carcinogenesis. Senescent cells contribute to the extension of chronic inflammation because of their secretory phenotype (SASP). Studies in cell culture, rodent models and clinical trials show that AISA can stop the inflammation and reverse the senescent phenotype. AISA d-Limonene is active in cancer therapy as well as to normalize silent inflammation in 65–85 years old otherwise healthy people. The inhibition of rho farnesylation seems to be at the basis of both anti-cancer and anti-inflammatory effects of the monoterpene d-Limonene. Abstract: Senescent cells have been suspected, because of their secretory phenotype (SASP or Senescence Associated Secretory Profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives) monoterpens have been characterized as possessing anti-inflammatory capacities in young cells submitted to pro-inflammatory cytokine stimulation. They have also been demonstrated to have the ability to act on senescent cells, reversing their characteristic pro-inflammatory phenotype. This is due to the fact that AISA act on the cytoskeleton scaffold of cells where actin polymerization induces the expression of adhesion molecules, fueling the infernal inflammatory loop. In comparison to other isoprenoid actives in degenerative diseases, the AISA monoterpene adds a mood-modulating capacity inducing the vagus nerve tone and its potent anti-inflammatory role.