Longitudinally extensive transverse myelitis after Campylobacter jejuni enteritis. Issue 2 (22nd December 2017)

• Record Type: Journal Article
• Authors: Llamas, Yudy; Hazel, Karl; Nicholson, Patrick; Costelloe, Lisa
• Is Part Of: Practical neurology. Volume 18:Issue 2(2018)
• Page Start: 143
• Page End: 145
• Publication Date: 2017-12-22
• Subjects: campylobacter -- ganglioside -- myelopathy; Neurology -- Periodicals; 616.8005
• DOI: 10.1136/practneurol-2017-001777
• Languages: English
• ISSNs: 1474-7758

Abstract

Abstract : Campylobacter jejuni infection is well-known to precipitate Guillain-Barré syndrome through an immune-mediated attack on the peripheral nervous system. Molecular mimicry between C. jejuni lipo-oligosaccharides on the surface of infectious agents and human gangliosides in the peripheral nerves induces cross-reactive immune responses. Although gangliosides also occur in the central nervous system (CNS), autoimmune CNS disorders rarely follow C . jejuni infections. However, longitudinally extensive transverse myelitis commonly has a parainfectious cause, triggered by a wide range of micro-organisms including viruses and bacteria. We report a patient who developed longitudinally extensive transverse myelitis after C . jejuni enteritis associated with antiganglioside antibodies.