Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. Issue 1 (23rd December 2003)

• Record Type: Journal Article
• Authors: Barwell, N; Howatson, R; Jackson, R; Johnson, A; Jarrett, R F; Cook, G
• Is Part Of: Journal of clinical pathology. Volume 57:Issue 1(2004)
• Page Start: 87
• Page End: 89
• Publication Date: 2003-12-23
• Subjects: interdigitating dendritic cell sarcoma -- Kaposi's sarcoma associated herpes virus -- Epstein-Barr virus; EBV, Epstein-Barr virus -- FDC, follicular dendritic cell -- HHV, human herpesvirus -- IDC, interdigitating dendritic cell -- IDCS, interdigitating dendritic cell sarcoma -- IgH, immunoglobulin heavy chain -- PCR, polymerase chain reaction -- TCR, T cell receptor; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.57.1.87
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from professional antigen presenting cells. This report describes a case of IDCS arising in the salivary gland associated lymphoid tissue of the parotid gland of a 51 year woman, presenting with a painless neck swelling. Histologically, sheets of S100 + /Ccd68 + /CD45 + /CD34 − /CD1a − spindle cells were surrounded with an inflammatory infiltrate with no evidence of B or T cell clonal proliferations. No evidence of either human herpesvirus 8 or Epstein-Barr virus could be detected by quantitative polymerase chain reaction in the tumour cells with serological evidence of previous Epstein-Barr virus infection. The patient remains well and disease free 24 months after presentation without specific treatment.