AB0434 The Role of IGG Anti β2-GPI in The Clinical Manifestations of Systemic Lupus Erythematosus. (15th July 2016)

• Record Type: Journal Article
• Authors: Mahendran, B.; Sankalingam, R.; Mohanasundaram, K.; Sankaran, S.; Mani, M.; Chilukuri, B.
• Is Part Of: Annals of the rheumatic diseases. Volume 75(2016)Supplement 2
• Page Start: 1055
• Page End: 1055
• Publication Date: 2016-07-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2016-eular.2603
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Beta 2 GPI is an important antigenic target for antiphospholipid antibodies. The role of IgG antibodies to β2 glycoprotein I [Anti-β2-GPI] has been well defined in antiphospholipid antibody syndrome but its role in the clinical manifestions of SLE remains elusive. Objectives: To investigate the role of Anti-β2-GPI in the clinical manifestations of SLE Methods: IgG Anti-β2-GPI was measured in 184 patients with SLE (93% women, mean age 28 years). IgG Anti-β2-GPI (>18 GPL units) was found in 19 patients (10.3%). Associations were determined with clinical manifestations of SLE and with components of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index Results: Of the patients with SLE who demonstrated IgG Anti-β2-GPI, 31% had at least one thrombotic event (OR 4.2, p=0.01), 26% had pulmonary hypertension (OR 3.2, p=0.02) and 26% had recurrent abortions (OR 4.1, p=0.02). IgG Anti-β2-GPI was protective against lupus nephritis (OR 0.31, p=0.02). No other manifestations were significantly higher in patients with IgG Anti-β2-GPI positivity Conclusions: In SLE, IgG Anti-β2-GPI is associated with thrombotic events and pulmonary hypertension, but may have a protective effect against lupus nephritis. Large scale studies are required to confirm these findings. References: Vikerfors A, Johansson AB, Gustafsson JT, Jönsen A, Leonard D, Zickert A et al. Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays. Rheumatology (Oxford). 2013 Mar;52(3):501–9. Meroni PL, Raschi E, Grossi C, Pregnolato F, Trespidi L, Acaia B et al. Obstetric and vascular APS: same autoantibodies but different diseases? Lupus. 2012 Jun;21(7):708–10. Matsuura E, Shen L, Matsunami Y, Quan N, Makarova M, Geske FJ et al. Pathophysiology of beta2-glycoprotein I in antiphospholipid syndrome. Lupus. 2010 Apr;19(4):379–84. Disclosure of Interest: None declared