Primary Open-angle Glaucoma and Increased Risk of Chronic Kidney Disease. Issue 12 (December 2019)

• Record Type: Journal Article
• Authors: Park, Sang Jun; Byun, Seong Jun; Park, Jae Yoon; Kim, Martha
• Is Part Of: Journal of glaucoma. Volume 28:Issue 12(2019)
• Publication Date: 2019-12
• Subjects: primary open-angle glaucoma -- chronic kidney disease -- health insurance database -- topical drugs; Glaucoma -- Periodicals; 617.741005
• DOI: 10.1097/IJG.0000000000001390
• Languages: English
• ISSNs: 1057-0829

Abstract

Abstract : Precis: The association between primary open-angle glaucoma (POAG) and subsequent development of chronic kidney disease (CKD) was investigated using a nationwide, population-based, retrospective cohort in South Korea. POAG increases the risk of subsequent CKD development. Purpose: The purpose of this study was to investigate the risk of subsequent CKD development in patients with POAG. Methods: In this nationwide, population-based longitudinal cohort, 1, 025, 340 beneficiaries in the 2002-2013 Korean National Health Insurance database were included. We identified patients with incident POAG and evaluated the risk of subsequent CKD development using diagnostic codes from the database after 2-year wash-out periods. We applied time-varying covariate Cox regression analyses to determine the effect of POAG on the development of CKD: Model 1 included only POAG as a time-varying covariate; Model 2 included Model 1 and demographic information; and Model 3 included Model 2, comorbidity, comedication, and the Charlson Comorbidity Index score. Results: The fixed cohort included 478, 303 eligible subjects, and of these subjects, 1749 suffered incident POAG, and 3157 developed CKD. POAG was associated with an increased risk of CKD development [hazard ratio (HR)=7.63; 95% confidence interval (CI), 5.89-9.87] in Model 1; HR=3.54 (95% CI, 2.73-4.58) in Model 2; and HR=2.90 (95% CI, 2.24-3.76) in Model 3]. Conclusion: POAG increased the risk of subsequent CKD in the general population, suggesting that POAG and CKD might share a common pathogenic mechanism. Abstract : Supplemental Digital Content is available in the text.