Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the pacman cohort. (December 2013)

• Record Type: Journal Article
• Authors: Zuurhout, Miranda JL; Vijverberg, Susanne JH; Raaijmakers, Jan AM; Koenderman, Leo; Postma, Dirkje S; Koppelman, Gerard H; Maitland-van der Zee, Anke Hilse
• Is Part Of: Pharmacogenomics. Volume 14:Number 16(2013)
• Page Start: 1965
• Page End: 1971
• Publication Date: 2013-12
• Subjects: ADRB2 -- Arg16 -- asthma -- children -- corticosteroids -- exacerbations -- long-acting adrenergic β2-receptor agonists -- pharmacogenetics; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.13.200
• Languages: English
• ISSNs: 1462-2416

Abstract

Background: Current evidence suggests that asthma patients with the ADRB2 Arg16 genotype have a poorer response to long-acting β2 -agonists (LABA), but the results remain inconsistent.Aim: This study assessed the association between Arg16 variants and treatment outcome in children treated with inhaled corticosteroids (ICS) and LABA.Materials & methods: ADRB2 Arg16 was genotyped in 597 children (4–12 years of age) participating in the PACMAN cohort study. A questionnaire was used to assess asthma control, frequency of asthma-related emergency department visits and use of oral corticosteroids in the past year.Results: Arg/Arg carriers with a reported use of ICS and LABA had an increased risk of oral corticosteroid use (odds ratio: 14.9; 95% CI: 1.59–140.1) and emergency department visits in the past year (odds ratio: 11.9; 95% CI: 1.22–115.8) compared to Gly/Gly carriers. This effect was not observed in Arg/Arg genotype carriers reporting ICS use only.Conclusion: Children who are homozygous for ADRB2 Arg16 have an increased risk of exacerbations when treated with combined LABA and ICS. Original submitted 4 September 2013; Revision submitted 27 September 2013