Additive manufacturing of electrochemical interfaces: Simultaneous detection of biomarkers. (September 2018)

• Record Type: Journal Article
• Authors: Ho, Eugene Hong Zhuang; Ambrosi, Adriano; Pumera, Martin
• Is Part Of: Applied materials today. Volume 12(2018)
• Page Start: 43
• Page End: 50
• Publication Date: 2018-09
• Subjects: 3D-printing -- Electrochemistry -- Electroplating -- Gold electrode -- Ascorbic acid -- Uric acid; Materials science -- Periodicals; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1016/j.apmt.2018.03.008
• Languages: English
• ISSNs: 2352-9407

Abstract

Graphical abstract: Highlights: Metal electrode of 3D structure was 3D printed. 3D metal electrodes were electrochemically coated with gold layer. Proof-of-concept of biomarkers electrochemical detection is carried out on 3D printed electrode. Abstract: 3D-printed stainless steel helical shaped electrodes with or without surface modification with a gold (Au) film are tested as novel electrode materials for the electrochemical detection of ascorbic acid and uric acid in aqueous solutions. Their performance in terms of sensitivity, selectivity and reproducibility is evaluated and compared to conventional glassy carbon electrode (GCE). Owing to the excellent electrocatalytic properties of the 3D-printed gold (Au) electrode, a clear separation between the anodic oxidation signal of ascorbic acid and uric acid in differential pulse voltammogram (DPV) could be obtained, allowing simultaneous quantification of these biomarkers. The oxidation current obtained using the 3D-printed Au electrode increased linearly with its respective biomarkers concentration in the range of 0.1–1 mM. Furthermore, the 3D-printed Au electrode generally performed better in terms of sensitivity and detection limits as compared to GCE. A real sample analysis of Vitamin C tablet (500 mg), Vitacimin was conducted using the 3D-printed Au electrode obtaining a variation from claimed concentration of ascorbic acid of only about 0.5%. Therefore, electrodes fabricated by 3D printing would certainly represent a viable alternative to conventional electrodes for efficient electrochemical analysis in the future.