Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: is hepatic venous pressure gradient a better end point?. Issue 3 (1st March 2002)

• Record Type: Journal Article
• Authors: Burroughs, A K; Groszmann, R; Bosch, J; Grace, N; Garcia-Tsao, G; Patch, D; Garcia-Pagan, J C; Dagher, L
• Is Part Of: Gut. Volume 50:Issue 3(2002)
• Page Start: 425
• Page End: 427
• Publication Date: 2002-03-01
• Subjects: antiviral therapy -- hepatitis C -- hepatic venous pressure gradient; HCV, hepatitis C virus -- PCR, polymerase chain reaction -- HVPG, hepatic venous pressure gradient -- WHVP, wedge hepatic venous pressure; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.50.3.425
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Chronic hepatitis C is a major healthcare problem. The response to antiviral therapy for patients with chronic hepatitis C has previously been defined biochemically and by PCR. However, changes in the hepatic venous pressure gradient (HVPG) may be considered as an adjunctive end point for the therapeutic evaluation of antiviral therapy in chronic hepatitis C. It is a validated technique which is safe, well tolerated, well established, and reproducible. Serial HVPG measurements may be the best way to evaluate response to therapy in chronic hepatitis C.