Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: synthesis and drug release. (March 2017)

• Record Type: Journal Article
• Authors: Katas, Haliza; Wen, Chai Yi; Siddique, Muhammad Irfan; Hussain, Zahid; Mohd Fadhil, Fatin Hanini
• Is Part Of: Therapeutic delivery. Volume 8:Number 3(2017)
• Page Start: 137
• Page End: 150
• Publication Date: 2017-03
• Subjects: nanotechnology -- RNA interfering -- topical delivery; Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde-2016-0075
• Languages: English
• ISSNs: 2041-5990

Abstract

Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing.Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel ), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17–320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23–28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h.Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.