Fluorine-18 patents (2009–2015). Part 2: new radiochemistry. (September 2016)

• Record Type: Journal Article
• Authors: Mossine, Andrew V; Thompson, Stephen; Brooks, Allen F; Sowa, Alexandra R; Miller, Jason M; Scott, Peter JH
• Is Part Of: Pharmaceutical patent analyst. Volume 5:Number 5(2016)
• Page Start: 319
• Page End: 349
• Publication Date: 2016-09
• Subjects: 18F -- fluorine-18 -- PET radiotracers -- positron emission tomography -- radiochemistry; Drugs -- Patents -- Periodicals; Drug development -- Periodicals; 615.1
• DOI: 10.4155/ppa-2016-0028
• Languages: English
• ISSNs: 2046-8954

Abstract

Fluorine-18 ( 18 F) is one of the most common positron-emitting radionuclides used in the synthesis of positron emission tomography radiotracers due to its ready availability, convenient half-life and outstanding imaging properties. In Part 1 of this review, we presented the first analysis of patents issued for novel radiotracers labeled with fluorine-18. In Part 2, we follow-up with a focus on patents issued for new radiochemistry methodology using fluorine-18 issued between January 2009 and December 2015.