Herpes Simplex Virus Type 1 Pneumonia—A Review. (December 2021)

• Record Type: Journal Article
• Authors: Jellinge, Marlene Ersgaard; Hansen, Frank; Coia, John Eugenio; Song, Zhijun
• Is Part Of: Journal of intensive care medicine. Volume 36:Number 12(2021)
• Page Start: 1398
• Page End: 1402
• Publication Date: 2021-12
• Subjects: herpes simplex virus pneumonia -- critically ill patients -- intensive care unit -- immunocompromised; Critical care medicine -- Periodicals; Critical Care -- Periodicals; Soins intensifs -- Périodiques; Soins intensifs; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.02805
• DOI: 10.1177/0885066620965941
• Languages: English
• ISSNs: 0885-0666

Abstract

Background: Pneumonia due to herpes simplex virus (HSV) is uncommon but can be seen in immunocompromised patients and has been associated with poor prognosis in this population. Aim: The aim was to study the results, outcome and mortality of HSV pneumonia in immunocompromised patients and patients receiving mechanical ventilation. Furthermore, it has been unclear whether to initiate prophylactic treatment with acyclovir or not. Methods: We have conducted a literature search using the keywords herpes simplex pneumonia, critically ill patients and intensive care unit for identification of relevant publications. Findings: HSV pneumonia can cause severe infection or even death in immunocompromised patients and critically ill patients. A clear diagnosis of HSV pneumonia can be difficult to establish. Respiratory condition may improve after initiation of acyclovir but data is scarce. Conclusion: HSV pneumonia should be considered in the immunocompromised patient and/or the intensive care patient who continues to deteriorate despite appropriate treatment. The value of prophylactic treatment with acyclovir is unproven but should be considered.