Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. (November 2013)

• Record Type: Journal Article
• Authors: Cornejo-García, José Antonio; Liou, Lieh-Bang; Blanca-López, Natalia; Doña, Inmaculada; Chen, Chien-Hsiun; Chou, Yi-Chun; Chuang, Hui-Ping; Wu, Jer-Yuarn; Chen, Yuan-Tsong; Plaza-Serón, María del Carmen; Mayorga, Cristobalina; Guéant-Rodríguez, Rosa María; Lin, Shih-Chang; Torres, María José; Campo, Paloma; Rondón, Carmen; Laguna, José Julio; Fernández, Javier; Guéant, Jean-Louis; Canto, Gabriela; Blanca, Miguel; Lee, Ming Ta Michael
• Is Part Of: Pharmacogenomics. Volume 14:Number 15(2013)
• Page Start: 1857
• Page End: 1869
• Publication Date: 2013-11
• Subjects: acute urticaria/angioedema -- drug hypersensitivity -- genome-wide association study -- mast cells -- NSAIDs; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.13.166
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA.Materials & methods: A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese).Results: Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group ( RIMS1, BICC1 and RAD51L 1 ) and one region in the Han Chinese population ( ABI3BP ). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7 . A majority of these genes are related to Ca 2+, cAMP and/or P53 signaling pathways.Conclusion: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA. Original submitted 7 June 2013; Revision submitted 19 August 2013