Effect of extended-release quetiapine fumarate on quality of life and sleep in elderly patients with generalized anxiety disorder. (December 2013)

• Record Type: Journal Article
• Authors: Datto, Catherine; Svedsäter, Henrik; Locklear, Julie C; Endicott, Jean
• Is Part Of: Neuropsychiatry. Volume 3:Number 6(2013)
• Page Start: 577
• Page End: 585
• Publication Date: 2013-12
• Subjects: Psychology, Pathological -- Periodicals; Mental illness -- Periodicals; Neuropsychiatry -- Periodicals; Mental Disorders -- Periodicals; Nervous System Diseases -- Periodicals; Neuropsychiatry -- Periodicals; Mental illness; Neuropsychiatry; Psychology, Pathological; 616.8
• DOI: 10.2217/npy.13.77
• Languages: English
• ISSNs: 1758-2008

Abstract

SUMMARY Aims: This prospectively planned analysis evaluates the effects of extended-release quetiapine fumarate (quetiapine XR) on quality of life and sleep quality in elderly patients (aged ≥66 years) with generalized anxiety disorder.Methods: Patients were randomized to quetiapine XR (flexible dosing 50–300 mg/day; n = 223) or placebo (n = 227). The primary end point was least squares mean change from baseline to week 9 in Hamilton Rating Scale for Anxiety total score. Secondary end points were patient-reported outcomes Quality of Life, Enjoyment and Satisfaction Questionnaire (Q-LES-Q)-Short Form percentage maximum total, Q-LES-Q item 15 ('satisfaction with medication'), Q-LES-Q item 16 ('overall life satisfaction') and Pittsburgh Sleep Quality Index global scores.Results: At week 9, quetiapine XR significantly improved the Hamilton Rating Scale for Anxiety total score versus placebo (least squares mean change: -14.97 vs -7.21; p < 0.001). Improvement was also observed in Q-LES-Q-Short Form percentage maximum total score, Q-LES-Q item 15 and 16 scores and Pittsburgh Sleep Quality Index global score for quetiapine versus placebo.Conclusion: In elderly patients with generalized anxiety disorder, quetiapine XR monotherapy (50–300 mg/day flexibly dosed) improved patients' quality of life, enjoyment, satisfaction and sleep quality.