Fatty acid and mineral receptors as drug targets for gastrointestinal disorders. (March 2017)

• Record Type: Journal Article
• Authors: Pongkorpsakol, Pawin; Moonwiriyakit, Aekkacha; Muanprasat, Chatchai
• Is Part Of: Future medicinal chemistry. Volume 9:Number 3(2017)
• Page Start: 315
• Page End: 334
• Publication Date: 2017-03
• Subjects: calcium-sensing receptor -- fatty acid receptors -- zinc-sensing receptor; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc-2016-0205
• Languages: English
• ISSNs: 1756-8919

Abstract

Nutrient-sensing receptors, including fatty acid receptors (FFA1–FFA4), Ca 2+ -sensing receptors and Zn 2+ -sensing receptors, are involved in several biological processes. These receptors are abundantly expressed in the GI tract, where they have been shown to play crucial roles in regulating GI function. This review provides an overview of the GI functions of fatty acid and mineral receptors, including the regulation of gastric and enteroendocrine functions, GI motility, ion transport and cell growth. Recently, several lines of evidence have implicated these receptors as promising therapeutic targets for the treatment of GI disorders, for example, inflammatory bowel disease, colorectal cancer, metabolic syndrome and diarrheal diseases. A future perspective on drug discovery research targeting these receptors is discussed.