New Delhi metallo-β-lactamase-producing Acinetobacter baumannii: a novel paradigm for spreading antibiotic resistance genes. (January 2014)

• Record Type: Journal Article
• Authors: Bonnin, Rémy A; Poirel, Laurent; Nordmann, Patrice
• Is Part Of: Future microbiology. Volume 9:Number 1(2014:Jan.)
• Page Start: 33
• Page End: 41
• Publication Date: 2014-01
• Subjects: β-lactamase -- antibiotic resistance -- carbapenemase -- Gram-negative rods; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.13.69
• Languages: English
• ISSNs: 1746-0913

Abstract

The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and Pseudomonas aeruginosa . However, recent findings regarding the spread of the bla NDM carbapenemase genes revealed that A. baumannii likely acts as a source of emerging antibiotic resistance genes. The analysis of genetic structure surrounding the bla NDM-1 gene revealed that the genetic structure (Tn 125 ) responsible for its dissemination most probably originates from Acinetobacter . Moreover, analysis of the bla NDM-1 gene itself demonstrated that it might be constructed in Acinetobacter through a recombination event with another resistance gene found in A. baumannii ( aphA6 ). This novel paradigm highlights a novel and unexpected role played by A. baumannii .