Multiple osteolytic primary peripheral T-cell bone lymphoma: the first case report. Issue 10 (October 2021)

• Record Type: Journal Article
• Authors: Li, Chen; Wang, Weiguo; Xu, Lingyun; Zheng, Dingyun; Zhang, Miao; Zhang, Qin; Wu, Xiaoqian; Yao, Yue; Huang, Wenyue; Li, Xue; Ying, Peipei; Wang, Xiuxiu; Shang, Liu; Feng, Yuhu
• Is Part Of: Journal of international medical research. Volume 49:Issue 10(2021)
• Publication Date: 2021-10
• Subjects: Lymphoma -- T-cell lymphoma -- peripheral T-cell lymphoma -- primary bone lymphoma -- osteolysis -- chemotherapy -- case report; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605211052229
• Languages: English
• ISSNs: 0300-0605

Abstract

Peripheral T-cell lymphoma accounts for about 10% of all cases of non-Hodgkin's lymphoma. However, less than 5% of patients with non-Hodgkin's lymphoma present with hypercalcaemia as the initial symptom, and less than 1% present with primary bone lesions. We herein describe a 76-year-old Chinese man who was diagnosed with primary bone adult T-cell lymphoma with extensive osteolysis, including bone loss in the radius, as the initial manifestation. He had developed severe generalised bone pain and an inability to raise his arms. X-ray examination revealed osteolytic destruction of the forearm with loss of the radial diaphysis. The patient was diagnosed with peripheral T-cell lymphoma based on his immunohistochemical results. He began treatment with the CHOPE chemotherapy regimen, which resulted in significant improvement of his bone pain.