Increased N-terminal CgA in circulation associated with cardiac reperfusion in pigs. (December 2013)

• Record Type: Journal Article
• Authors: Frydland, Martin; Kousholt, Birgitte; Larsen, Jens Rolighed; Burnettr, John C; Hilsted, Linda; Hasenkam, J Michael; Goetze, Jens Peter
• Is Part Of: Biomarkers in medicine. Volume 7:Number 6(2013)
• Page Start: 959
• Page End: 967
• Publication Date: 2013-12
• Subjects: CgA -- chromogranin A -- ischemia/reperfusion -- myocardial infarction -- natriuretic peptides -- neuroendocrine response -- pig; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.13.92
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: Acute myocardial infarction causes neurohumoral activation characterized by increased sympathetic activity. CgA is a protein released during sympathoadrenal stress from neuroendocrine tissue. Recently, increased CgA concentrations in circulation have been reported and suggested to be an independent predictor of mortality after acute myocardial infarction.Materials & methods: Eighteen pigs underwent 1 h of regional myocardial ischemia followed by 3 h of reperfusion. Blood samples were collected every hour and plasma CgA was measured with two radioimmunoassays.Results: We found a 30% increase in plasma N-terminal CgA 1 h after re-establishment of coronary blood supply. On the other hand, plasma pancreastatin did not change in response to ischemia or reperfusion but decreased during the entire experiment.Conclusion: Our results suggest a differentiated CgA response in myocardial reperfusion after local cardiac anoxia that may reflect tissue-specific post-translational processing and release.