Design, modification and in vitro evaluation of pectin's bucco-adhesiveness. (June 2016)

• Record Type: Journal Article
• Authors: Laffleur, Flavia; Zilio, Martina; Menzel, Claudia; Lupo, Noemi; Schmutzler, Matthias
• Is Part Of: Therapeutic delivery. Volume 7:Number 6(2016)
• Page Start: 369
• Page End: 375
• Publication Date: 2016-06
• Subjects: adhesive -- buccal -- mucosa -- mucoadhesion -- pectin; Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde-2016-0019
• Languages: English
• ISSNs: 2041-5990

Abstract

Aim: It was the aim of this study to synthesize pectin (PEC) with sulfhydryl groups and evaluate its suitability in buccal application.Materials & methods: Native PEC was chemically modified by covalent attachment of sulfhydryl-bearing cysteine (CYS). Stability assays in form of water uptake behavior and erosion study were performed. Additionally, mucoadhesive study on buccal mucosa was performed.Results: Pectin–cysteine (PECCYS) was successfully synthesized as proved by IR and Ellman's assay exhibiting 436.59 ± 127.87 µmol thiol groups per gram polymer. Stability assay showed that PECCYS revealed a 2.27-fold improved water uptake and mucoadhesiveness augmented 3.75-fold in comparison to unmodified PEC.Conclusion: PECCYS might be a future suitable excipient for buccal adhesive application.