Bioproduction of gold nanoparticles for photothermal therapy. (May 2016)

• Record Type: Journal Article
• Authors: Silva, Catarina Oliveira; Rijo, Patrícia; Molpeceres, Jesús; Ascensão, Lia; Roberto, Amílcar; Fernandes, Ana Sofia; Gomes, Ricardo; Pinto Coelho, João M; Gabriel, Ana; Vieira, Pedro; Reis, Catarina Pinto
• Is Part Of: Therapeutic delivery. Volume 7:Number 5(2016)
• Page Start: 287
• Page End: 304
• Publication Date: 2016-05
• Subjects: bioproduction -- gold nanoparticles -- photothermal therapy; Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde-2015-0011
• Languages: English
• ISSNs: 2041-5990

Abstract

Background: Photothermal response of plasmonic nanomaterials can be utilized for a number of therapeutic applications such as the ablation of solid tumors.Methods & results: Gold nanoparticles were prepared using different methods. After optimization, we applied an aqueous plant extract as the reducing and capping agent of gold and maximized the near-infrared absorption (650–900 nm). Resultant nanoparticles showed good biocompatibility when tested in vitro in human keratinocytes and yeast Saccharomyces cerevisiae . Gold nanoparticles were easily activated by controlled temperature with an ultrasonic water bath and application of a pulsed laser.Conclusion: These gold nanoparticles can be synthesized with reproducibility, modified with seemingly limitless chemical functional groups, with adequate controlled optical properties for laser phototherapy of tumors and targeted drug delivery.