Thermal potentiation of chemotherapy by magnetic nanoparticles. (October 2013)

• Record Type: Journal Article
• Authors: Torres-Lugo, Madeline; Rinaldi, Carlos
• Is Part Of: Nanomedicine. Volume 8:Number 10(2013)
• Page Start: 1689
• Page End: 1707
• Publication Date: 2013-10
• Subjects: magnetic fluid hyperthermia -- magnetic nanoparticle -- synergy -- thermal potentiation; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.13.146
• Languages: English
• ISSNs: 1743-5889

Abstract

Clinical studies have demonstrated the effectiveness of hyperthermia as an adjuvant for chemotherapy and radiotherapy. However, significant clinical challenges have been encountered, such as a broader spectrum of toxicity, lack of patient tolerance, temperature control and significant invasiveness. Hyperthermia induced by magnetic nanoparticles in high-frequency oscillating magnetic fields, commonly termed magnetic fluid hyperthermia, is a promising form of heat delivery in which thermal energy is supplied at the nanoscale to the tumor. This review discusses the mechanisms of heat dissipation of iron oxide-based magnetic nanoparticles, current methods and challenges to deliver heat in the clinic, and the current work related to the use of magnetic nanoparticles for the thermal-chemopotentiation of therapeutic drugs.